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desvenlafaxine will enhance the degree or result of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Desvenlafaxine inhibits CYP2D6; with better desvenlafaxine doses (ie, four hundred mg) reduce the CYP2D6 substrate dose by around fifty%; no dosage adjustment essential with desvenlafaxine doses 7 consecutive days quickly